Endocrine Abstracts

Advances in the diagnosis and treatment of childhood, adolescent and adult cancer have greatly increased the life expectancy of young women with cancer, but have resulted in a growing population of adolescent and adult long-term survivors of childhood malignancies, who may experience premature ovarian failure (POF) and infertility as a result of aggressive chemotherapy and radiotherapy treatments (indicated for both cancer and bone marrow transplantation (BMT)).<p class="a...

Introduction: The utility of serum calcitonin has been evaluated in a series of prospective, nonrandomized studies suggest that the use of routine serum calcitonin for screening may detect C-cell hyperplasia and medullary thyroid cancer at an earlier stage and overall survival may be improved. Elisei et al. estimated that routine measurement of plasma calcitonin in thyroid nodule patients would yield an additional 2.2 life-years per positive patient.<p class="abstex...

Background: The Mediterranean diet (MD) is the traditional diet of the people living in the Mediterranean basin and has been linked with positive health outcomes e.g. reduced incidence of cardiovascular and neoplastic disease. No study has investigated the relationship between the MD and glycaemic control in a Mediterranean population with type 1 diabetes mellitus (T1DM). Furthermore, it is unknown how well controlled are such patients and whether they follow the MD.<p cla...

Introduction: It is believed that key pathogenic mechanism of PCOS is hyperinsulinemia. Insulin synthesis is linked to C-peptide release, but the role of C-peptide in PCOS remains unknown.Methods: The aim of this study was to evaluate of C-peptide serum levels in obese women with PCOS with concomitant assessment of possible link between C-peptide concentrations and metabolic disturbances and androgens levels in those individuals.Si...

Primary squamous cell carcinoma of the thyroid gland (PSCCT) is a rare neoplasm of the thyroid with a poor prognosis. We present a 70-year-old male patient who presented with a progressively growing mass on the left side of the neck causing shortness of breath. The patient presented with suspicious poorly-differentiated malignancy as a result of the thyroid fine-needle aspiration cytology performed due to the rapidly growing mass. No other primary tumor focus was detected in t...

Background and aims: Depression is a common co-morbidity among people with diabetes that reduces quality of life and is associated with morbidity, mortality, and health care costs. We aimed to assess the prevalence of depression among patients with type 2 diabetes in two Arabic nations, Egypt and Yemen and to examine its relationship with socio-demographic data and diabetes complications.Methods: We conducted a cross-sectional analysis on 200 subjects wi...

Background and aims: Depression is a common co-morbidity among people with diabetes that reduces quality of life and is associated with morbidity, mortality, and health care costs. We aimed to assess the prevalence of depression among patients with type 2 diabetes in two Arabic nations, Egypt and Yemen and to examine its relationship with socio-demographic data and diabetes complications.Methods: We conducted a cross-sectional analysis on 200 subjects wi...

Introduction: Wolfram syndrome (WS) is a genetic disorder that affects the quality of life of very young Patients. This condition is also referred to as DIDMOAD (diabetes insipidus-diabetes mellitus-optic atrophy-deafness).characterized by non immunogenic diabetes mellitus, and a progressive atrophy of the optic nerve, which occurs generally in the first decade of life.In order to prevent and treat this condition, a better understanding of WS pathogenesi...

Background and Objective: Smoking increases the risk of Graves’ orbitopathy (GO) in patients with Graves’ disease (GD). Therefore, smoking cessation should be recommended to all patients with GD. This study aimed to investigate whether smoking cessation recommendations were taken into account in patients with GD and whether there was a difference in terms of smoking cessation between those with and without GO.Methods: Smoking status of the case...

Introduction: Daily administration of Pegvisomant normalizes IGF1 levels >71% of acromegalics (1). Few studies have assessed the efficacy of weekly administration. We assessed the efficacy of weekly pegvisomant for 12 months, after withdrawal of long-acting somatostatin analogs (SSA) in acromegalics previously controlled on combination therapy.Design: Fifteen subjects (8 males), age 58 (35–80) (median (range)) years on combination therapy of hig...